These Are the Best Supplements for Healthy Aging, According to Thorne’s Medical Affairs Experts

Healthy aging starts with daily habits — and for many, that includes smart, supportive supplementation. 

While there’s no one-size-fits-all formula for healthy aging, science continues to uncover promising ways to help support the body and mind through every decade. To help shed light on the most well-researched options, we turned to Dr. Jennifer Greer (ND, MEd), Senior Director of Medical Education at Thorne,  a premium supplement brand known for its evidence-based approach to wellness.

To help you find the best supplements for your healthy aging routine, we’re spotlighting Thorne supplements that may help support longevity, whether you’re focused on cellular health, cognitive function, or sustaining energy over time.* Each product featured has been thoughtfully selected by Thorne’s in-house team of healthcare professionals, and every formula reflects the brand’s commitment to rigorous testing and effective ingredients.

As always, Thrive Market is a trusted partner to help you explore your wellness goals. If you’re curious about ways to support your healthspan, read on to discover the expert-backed supplements that might fit your routine.

Creatine

What is it?

Creatine is an amino acid found mostly in your muscles and in the brain. It’s naturally produced in the body from other amino acids. Creatine is also found in foods like meats, eggs, and fish. It plays a vital role in the body’s production of cellular energy by helping to make ATP, a molecule needed for intense exercise, as well as for supplying the energy to pump your heart and power your brain.*

How does creatine help with healthy aging?

• It enhances strength and promotes lean body mass*
• It supports cognitive function and a healthy body composition, especially in the aging population*
• Helps the cells of the body more efficiently create cellular energy* 

Who should take creatine?

• Individuals who have an increased dietary need, such as athletes, or those who aren’t consuming enough creatine-containing foods in their normal diet
• Aging individuals seeking to support cognitive function and a healthy body composition
• Anyone wanting to promote lean body mass, strength, and exercise capacity

Try: Thorne Creatine 

This powdered creatine supplement can easily be mixed into water, juice, or any other beverage. Thorne’s creatine is made up of a highly researched, micronized form of creatine monohydrate that’s colorless, odorless, and easily dissolves in liquid. 

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Nicotinamide Riboside

What is nicotinamide riboside?

Nicotinamide riboside efficiently stimulates the production of NAD⁺ (nicotinamide adenine dinucleotide), an important coenzyme found in every cell and plays an integral role in multiple body functions.

How does nicotinamide riboside help with healthy aging?

The body’s natural level of NAD⁺ begins to decline significantly with age, which can lead to adverse effects of aging and age-related conditions. Nicotinamide riboside (NR) boosts NAD⁺ production to help mitigate this loss.*

Who should take nicotinamide riboside?

Anyone seeking support for healthy aging*

Try: Thorne ResveraCel 

ResveraCel combines NR with resveratrol, quercetin phytosome, and betaine to support healthy aging.*

The ingredients in ResveraCel support healthy cellular aging by acting as natural activators of the sirtuin proteins, an important class of enzymes that act as cellular switches to up-regulate numerous positive functions associated with aging. The ingredients in ResveraCel also benefit healthy aging by assisting with the elimination of aging cells (inactive, senescent); supporting optimal mitochondrial number, structure, and function; and promoting a healthy metabolism as you age.*

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Resveratrol

What is resveratrol? 

Resveratrol is a natural substance found in red wine, among other things. Resveratrol has shown promise in clinical studies by modulating the effects of several age-related conditions.*

How does resveratrol help with healthy aging?

• It supports the body’s normal inflammatory response and benefits blood vessels*
• It activates a special class of protein enzymes called sirtuins that act as cellular switches to mitigate cellular aging and support a balanced inflammatory response, detoxification, stress resistance, fat and glucose metabolism, and normal circadian rhythms*
• The sirtuin proteins support the formation of new mitochondria in the cells, which results in more efficient cellular energy production and healthy aging*

Who should take resveratrol?

Anyone seeking support for healthy aging

Try: Thorne ResveraCel 

ResveraCel combines nicotinamide riboside (a direct precursor to NAD⁺) with resveratrol, quercetin phytosome, and betaine to support healthy aging.*

The ingredients in ResveraCel support healthy cellular aging by acting as natural activators of the sirtuin proteins, an important class of enzymes that act as cellular switches to up-regulate numerous positive functions associated with aging. The ingredients in ResveraCel also benefit healthy aging by assisting with the elimination of aging cells (inactive, senescent), supporting optimal mitochondrial number, structure, and function, and promoting a healthy metabolism as you age.*

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Berberine

What is berberine?

Berberine is an alkaloid found in several plants — in Thorne’s case, Berberis aristata (Indian barberry). 

How does berberine help with healthy aging?

• It supports a healthy metabolism by promoting healthy blood sugar metabolism and insulin sensitivity and helping maintain healthy cholesterol and triglyceride levels*
• Studies have shown that Berberine can be effective in helping maintain a healthy body weight, decreased abdominal fat and waist:hip ratio, metabolism of fat in the liver, and body composition*
• It benefits GI Health by supporting a beneficial bacterial balance in the gut, helping to maintain a healthy microbiome, and supporting diversity of intestinal flora*

Who should take berberine?

• Individuals seeking support for metabolic, cardiovascular, and GI health
• Anyone wanting to maintain normal blood sugar and cholesterol levels
• Individuals who want additional support for maintaining a healthy gut microbiome

Try: Thorne Berberine 

Every capsule contains both berberine phytosome for enhanced absorption and the well-studied berberine HCl. The berberine is sourced from non-endangered species; grape seed extract in the phytosome matrix protects the GI tract from possible berberine irritation. 

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Quercetin 

What is quercetin?

Quercetin is a type of plant compound called a flavonoid (a fancy name for a plant pigment) that contributes to the natural, vibrant colors of fruits and vegetables like apples, onions, berries, and tea. Flavonoids function as antioxidants, seeking damaging free radicals and neutralizing them. Free radicals are caused by the daily oxidative stress placed on our bodies and are linked to cellular damage, accelerated aging, and chronic health conditions.  

How does quercetin help with healthy aging?

• It is one of only two nutrients that have been studied to reduce cellular senescence.* Senescent cells are malfunctioning cells that have stopped dividing but do not die and remain in the body. Environmental factors, along with regular aging, cause a buildup of senescent cells, which can be associated with biological aging and age-related disorders.
• It up-regulates sirtuins (key regulators of cellular health) associated with improved weight-related metabolic factors at the cellular level*
• The trio of sirtuin, senescence, and antioxidant support helps optimize healthy cellular aging*

Who should take quercetin?

• Aging individuals seeking nutritional support for oxidative stress, sirtuin activation, and to decrease senescent cells
• Anyone seeking support for seasonal allergies and respiratory health
• Athletes looking to promote athletic performance (running) and post-exercise recovery

Try: Thorne Quercetin Phytosome 

Quercetin Phytosome offers the antioxidant benefits of a flavonoid, as well as its immune-supporting properties and the ability to support a healthy inflammatory response, which provides a range of health-promoting benefits.* 

As a natural compound, quercetin is typically characterized by poor absorption into the bloodstream, which is why the quercetin used in Thorne products is provided as a quercetin phytosome. Thorne’s Quercetin Phytosome is up to 20-times more bioavailable than quercetin extract alone, for maximum benefit from a smaller amount.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.